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Products Details
Product Description
– Anticancer agent 133 (compound Rh2) is an anti-cancer agent with cytotoxic and antimetastatic activities. Anticancer agent 133 induces cell cycle arrest, apoptosis, and autophagy. Anticancer agent 133 also inhibits cell metastasis via suppression of EGFR expression mediated by FAK-regulated integrin β1[1].
Web ID
– HY-149344
Shipping
– Room temperature
Molecular Formula
– C24H19Cl3N5ORh
References
– [1]Gu YQ, et al. Rhodium(III)-Picolinamide Complexes Act as Anticancer and Antimetastasis Agents via Inducing Apoptosis and Autophagy. J Med Chem. 2023 Jul 27;66(14):9592-9606.
Molecular Weight
– 602.71
SMILES
– Cl[Rh]12(Cl)([N]#CC)[N]3=C(C(N2C4=CC=CC=C4)=O)C(Cl)=CC=C3N5C(C6=CC=CC=C6)=CC(C)=[N]51
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Autophagy;EGFR
Pathway
– Apoptosis;Autophagy;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
