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Products Details
Product Description
– Anticancer agent 127 (142D6) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 127 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC50s of 12 nM, 14 nM, and 9 nM, respectively. Anticancer agent 127 has anticancer effects[1].
Web ID
– HY-155018
Shipping
– Room temperature
Molecular Formula
– C26H37FN4O6S
References
– [1]Udompholkul P, et al. Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist. J Med Chem. 2023 Jun 22;66(12):8159-8169.
CAS Number
– 2410953-19-2
Molecular Weight
– 552.66
SMILES
– O=C(N1[C@H](C(N[C@H]2C(C=CC=C3OS(=O)(F)=O)=C3CC2)=O)CCC1)[C@H](C4CCCCC4)NC([C@H](C)NC)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– IAP
Pathway
– Apoptosis
Product type
– Reference compound
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