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Products Details
Product Description
– Anticancer agent 124 is an orally active, highly selective and potent pan RAF inhibitor. Anticancer agent 124 inhibits MAPK signalling in BRAF V600E, NRAS and KRAS mutant tumor cells[1].
Web ID
– HY-108887
Shipping
– Room temperature
Molecular Formula
– C26H21ClN4O3
References
– [1]Helen Mason, et al. Abstract 5160: Development of REDX05358, a novel highly selective and potent pan RAF inhibitor and a potential therapeutic for BRAF and RAS mutant tumors. Cancer Res 1 July 2017; 77 (13_Supplement): 5160.
CAS Number
– 1884226-20-3
Molecular Weight
– 472.92
SMILES
– O=C1NC2=C(C(OC3=CC=C4C(CC(C5=NC=C(C6=CC=CC=C6Cl)N5)CO4)=C3)=CC=N2)CC1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Raf
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
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