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Products Details
Product Description
– Antibiotic DC 81 (DC 81), an antitumor antibiotic produced by Streptomyces species, is a PBD (pyrrolo[2,1-c][1,4]benzodiazepine). Antibiotic DC 81 is potent inhibitor of nucleic acid synthesis. Antibiotic DC 81 can recognize and bind to specific sequences of DNA and form a labile covalent adduct[1][2].
Web ID
– HY-107767
Shipping
– Room temperature
Molecular Formula
– C13H14N2O3
References
– [1]Hu WP, et al. Biological evaluation of an antibiotic DC-81-indole conjugate agent in human melanoma cell lines. Kaohsiung J Med Sci. 2003 Jan;19(1):6-12. |[2]Lee CH, et al. Pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugate (IN6CPBD) has better efficacy and superior safety than the mother compound DC-81 in suppressing the growth of established melanoma in vivo. Chem Biol Interact. 2009 Aug 14;180(3):360-7.
CAS Number
– 81307-24-6
Molecular Weight
– 246.26
SMILES
– O=C1C2=CC(OC)=C(O)C=C2N=C[C@@]3([H])N1CCC3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– H2O
Target
– Antibiotic;Apoptosis;DNA/RNA Synthesis
Pathway
– Anti-infection;Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
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