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Products Details
Product Description
– Anti-inflammatory agent 22 (compound 14a) is an orally active anti-inflammatory agent. Anti-inflammatory agent 22 inhibits LPS-induced TNF-α production with an IC50 value of 14.6 μM. Anti-inflammatory agent 22 has preventive effects on lymphedematous tissue via suppression of adipogenesis. Anti-inflammatory agent 22 suppresses limb lymphedema volume in mice[1].
Web ID
– HY-146435
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H16O6
References
– [1]Roh K, et al. Synthesis and evaluation of butein derivatives for in vitro and in vivo inflammatory response suppression in lymphedema. Eur J Med Chem. 2020;197:112280.
CAS Number
– 2721484-76-8
Molecular Weight
– 376.36
SMILES
– O=C(C1=C(C=C(C=C1)O)OC(C2=CC=CC=C2)=O)/C=C/C3=CC=C(C(O)=C3)O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– TNF Receptor
Isoform
– CD40
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
