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Products Details
Product Description
– Anthramycin, a member of the pyrolobenzodiazepine (PBD) family, is a potent antibiotic. Anthramycin has potent antitumor activity. Anthramycin can act as an potent antagonist of cholecystokinin in the central nervous system in mice[1][2][3].
Web ID
– HY-150036
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C16H17N3O4
References
– [1]Haque T, et al. Topical delivery of anthramycin II. Influence of binary and ternary solvent systems. Eur J Pharm Sci. 2018 Aug 30;121:59-64.|[2]Kubota K, et al. Cholecystokinin antagonism by anthramycin, a benzodiazepine antibiotic, in the central nervous system in mice. Brain Res. 1989 Apr 17;485(1):62-6. |[3]Cargill C, et al. Effects of daunomycin and anthramycin on electrocardiogram and mitochondrial metabolism of the rat heart. J Natl Cancer Inst. 1974 Aug;53(2):481-6.
CAS Number
– 4803-27-4
Molecular Weight
– 315.32
SMILES
– O=C1N2[C@@]([C@H](NC3=C(O)C(C)=CC=C31)O)([H])CC(/C=C/C(N)=O)=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Cholecystokinin Receptor
Pathway
– Anti-infection;GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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