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Products Details
Product Description
– Androsta-1,4,6-triene-3,17-dione is a lipophilic and specific aromatase inhibitor with a Ki of 0.18 μM. Androsta-1,4,6-triene-3,17-dione inhibits estrogen biosynthesis and shows antifertility effects. Androsta-1,4,6-triene-3,17-dione induces impairment of spatial memory[1][2].
Web ID
– HY-136092
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C19H22O2
References
– [1]Covey DF, et al. Enzyme-generated intermediates derived from 4-androstene-3,6,17-trione and 1,4,6-androstatriene-3,17-dione cause a time-dependent decrease in human placental aromatase activity. Endocrinology. 1981 Apr;108(4):1597-9.|[2]Brodie AM, et al. Antifertility effects of an aromatase inhibitor, 1,4,6-androstatriene-3, 17-dione. Endocrinology. 1979 Jan;104(1):118-21.
CAS Number
– 633-35-2
Molecular Weight
– 282.38
SMILES
– C[C@]1([C@](CC2)([H])[C@]3([H])C=CC4=CC(C=C[C@]4(C)[C@@]3([H])CC1)=O)C2=O
Clinical Information
– No Development Reported
Research Area
– Endocrinology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Cytochrome P450
Isoform
– CYP19
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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