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Products Details
Product Description
– Androgen receptor-IN-6 (compound 16) is an orally available androgen receptor (Androgen Receptor) potent inhibitor (IC50=0.12 μM in vitro), targeting the disordered N-terminal domain (NTD). Androgen receptor-IN-6 has good Caco2 cell membrane permeability and has an oral activity (F/%) of 16% in male CD-1 mice[1].
Web ID
– HY-155478
Shipping
– Room temperature
Molecular Formula
– C16H15N3OS
References
– [1]Henry M C et al. Synthesis and evaluation of small molecule inhibitors of the androgen receptor N-terminal domain[J]. ACS Medicinal Chemistry Letters, 2023.
Molecular Weight
– 297.37
SMILES
– CN1C2=CC=C(C3=CC(C(N)=O)=CC=C3SC)C=C2C=N1
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Androgen Receptor
Pathway
– Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
