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Products Details
Product Description
– Anastrozole-d12 is the deuterium labeled Anastrozole. Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC50 of 15 nM[1][2].
Web ID
– HY-14274S
Shipping
– Room temperature
Molecular Formula
– C17H7D12N5
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Dukes M, et al. The preclinical pharmacology of “Arimidex” (anastrozole; ZD1033)–a potent, selective aromatase inhibitor. J Steroid Biochem Mol Biol. 1996 Jul;58(4):439-45.
CAS Number
– 120512-32-5
Molecular Weight
– 305.44
SMILES
– N#CC(C([2H])([2H])[2H])(C1=CC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C#N)=CC(CN2C=NC=N2)=C1)C([2H])([2H])[2H]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Cytochrome P450;Isotope-Labeled Compounds
Isoform
– CYP19
Pathway
– Metabolic Enzyme/Protease;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
