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Amitriptyline (hydrochloride)
$55 – $106
Products Details
Product Description
– Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity[1][2][3].
Web ID
– HY-B0527A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C20H24ClN
References
– [1]Jang, S.W., et al., Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem Biol, 2009. 16(6): p. 644-56.|[2]Kim Lawson. A Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia. Biomedicines. 2017 Jun; 5(2): 24.|[3]S Neil Vaishnavi , et al. Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity. Biol Psychiatry. 2004 Feb 1;55(3):320-2.|[4]Ghelardini C, et al. Antinociception induced by amitriptyline and imipramine is mediated by alpha2A-adrenoceptors. Jpn J Pharmacol. 2000 Feb;82(2):130-7.
CAS Number
– 549-18-8
Molecular Weight
– 313.86
Compound Purity
– 99.28
SMILES
– CN(C)CC/C=C1C2=CC=CC=C2CCC3=C1C=CC=C3.Cl
Clinical Information
– Launched
Research Area
– Neurological Disease; Cancer
Solubility
– DMSO : ≥ 100 mg/mL|H2O : ≥ 50 mg/mL
Target
– 5-HT Receptor;Adrenergic Receptor;Histamine Receptor;mAChR;Serotonin Transporter;Sodium Channel;Trk Receptor
Isoform
– 5-HT1 Receptor;5-HT2 Receptor;H1 Receptor;H3 Receptor;H4 Receptor;TrkA;TrkB
Pathway
– GPCR/G Protein;Immunology/Inflammation;Membrane Transporter/Ion Channel;Neuronal Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
