Download Files:
Products Details
Product Description
– Amiloride-15N3 (hydrochloride) is the 15N labeled Amiloride hydrochloride[1]. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC[2]) and urokinase-type plasminogen activator receptor (uTPA[3]). Amiloride hydrochloride is a blocker of polycystin-2 (PC2;TRPP2[4]) channel.
Web ID
– HY-B0285AS
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C6H9Cl2N4 15N3O
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Ji, H.L., et al. delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Physiol Lung Cell Mol Physiol, 2012. 303(12): p. L1013-26.|[3]Teiwes J, et al. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan20(1):109-17.|[4]Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 729(7):1176-91.
CAS Number
– 1216796-18-7
Molecular Weight
– 269.07
SMILES
– [15NH]=C([15NH2])[15NH]C(C1=NC(Cl)=C(N)N=C1N)=O.Cl
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Sodium Channel;TRP Channel
Pathway
– Apoptosis;Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
