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Products Details
Product Description
– Amiloride-15N3 (hydrochloride) is the 15N labeled Amiloride hydrochloride[1]. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC[2]) and urokinase-type plasminogen activator receptor (uTPA[3]). Amiloride hydrochloride is a blocker of polycystin-2 (PC2;TRPP2[4]) channel.
Web ID
– HY-B0285AS
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C6H9Cl2N4 15N3O
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Ji, H.L., et al. delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Physiol Lung Cell Mol Physiol, 2012. 303(12): p. L1013-26.|[3]Teiwes J, et al. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan20(1):109-17.|[4]Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 729(7):1176-91.
CAS Number
– 1216796-18-7
Molecular Weight
– 269.07
SMILES
– [15NH]=C([15NH2])[15NH]C(C1=NC(Cl)=C(N)N=C1N)=O.Cl
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Sodium Channel;TRP Channel
Pathway
– Apoptosis;Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Isotope-Labeled Compounds
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