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Amifostine
$41 – $272
Products Details
Product Description
– Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action[1][2][3][4].
Web ID
– HY-B0639
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C5H15N2O3PS
References
– [1]Shao-Ze Wu, et al. Amifostine Pretreatment Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Apoptosis and Oxidative Stress. Oxid Med Cell Longev. 2017;2017:4130824.|[2]D Maurici, et al. Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay. Oncogene. 2001 Jun 14;20(27):3533-40.|[3]Efstathia Giannopoulou, et al. Amifostine inhibits angiogenesis in vivo. J Pharmacol Exp Ther. 2003 Feb;304(2):729-37.|[4]Michael I Koukourakis, et al. Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha. Cancer Chemother Pharmacol. 2004 Jan;53(1):8-14.|[5]Kouvaris, J.R., V.E. Kouloulias, and L.J. Vlahos, Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist, 2007. 12(6): p. 738-47.
CAS Number
– 20537-88-6
Molecular Weight
– 214.22
Compound Purity
– 98.0
SMILES
– OP(SCCNCCCN)(O)=O
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– DMF : 1 mg/mL (ultrasonic)|DMSO : < 1 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Target
– HIF/HIF Prolyl-Hydroxylase;MDM-2/p53
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
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