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Products Details
Product Description
– AMG0347 is a transient receptor potential type V1 receptor antagonist. AMG0347 inhibits activation of the rat TRPV1 channel by heat (IC50 = 0.2 nm), protons (IC50= 0.8 nm), or capsaicin (IC50 = 0.7 nm)[1].
Web ID
– HY-111036
Shipping
– Room temperature
Molecular Formula
– C24H26F3N3O2
References
– [1]Chaoran Wu, et al. Effect of AMG0347, a Transient Receptor Potential Type V1 Receptor Antagonist, and Morphine on Pain Behavior after Plantar Incision。Anesthesiology. 2008 Jun;108(6):1100-8.
CAS Number
– 946615-43-6
Molecular Weight
– 445.48
SMILES
– O=C(NC1=C2CC(O)CCC2=CC=C1)/C=C/C3=CC=C(C(F)(F)F)N=C3N4CCCCC4
Clinical Information
– No Development Reported
Research Area
– others
Solubility
– 10 mM in DMSO
Target
– TRP Channel
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
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