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AMG 925 (HCl)
$85 – $550
Products Details
Product Description
– AMG 925 HCl is a potent, selective, and orally available FLT3/CDK4 dual inhibitor with IC50s of 2±1 nM and 3±1 nM, respectively.
Web ID
– HY-15889A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C26H30ClN7O2
References
– [1]Keegan K, et al. Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia. Mol Cancer Ther. 2014 Apr;13(4):880-9.
CAS Number
– 1401034-19-2
Molecular Weight
– 508.02
SMILES
– OCC(N1CC2=C(N=C(NC3=NC=C4C(N([C@H]5CC[C@H](C)CC5)C6=CN=CC=C64)=N3)C=C2)CC1)=O.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– CDK;FLT3
Isoform
– CDK1;CDK2;CDK4;CDK6
Pathway
– Cell Cycle/DNA Damage;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
