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Product Description
– Amantadine (1-Adamantanamine) sulfate is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine sulfate inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine sulfate also has anti-orthopoxvirus and anticancer activity. Amantadine sulfate can be used for Parkinson’s disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[1][2][3][4][5][6].
Web ID
– HY-B0402B
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C10H17N.1/2H2O4S
References
– [1]Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 2015;36(3):904-910.|[2]Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200.|[3]Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099.|[4]Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52. |[5]Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 24;13(4):539. |[6]Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct;121(4):773-85.
CAS Number
– 31377-23-8
Molecular Weight
– 200.18
SMILES
– NC1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1.O=S(O)(O)=O.[1/2]
Clinical Information
– Launched
Research Area
– Cancer; Infection; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Bcl-2 Family;CDK;Influenza Virus;Orthopoxvirus;SARS-CoV
Isoform
– Bax;Bcl-2;CDK2
Pathway
– Anti-infection;Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
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