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Product Description
– Amantadine (1-Adamantanamine) sulfate is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine sulfate inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine sulfate also has anti-orthopoxvirus and anticancer activity. Amantadine sulfate can be used for Parkinson’s disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[1][2][3][4][5][6].
Web ID
– HY-B0402B
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C10H17N.1/2H2O4S
References
– [1]Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 2015;36(3):904-910.|[2]Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200.|[3]Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099.|[4]Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52. |[5]Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 24;13(4):539. |[6]Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct;121(4):773-85.
CAS Number
– 31377-23-8
Molecular Weight
– 200.18
SMILES
– NC1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1.O=S(O)(O)=O.[1/2]
Clinical Information
– Launched
Research Area
– Cancer; Infection; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Bcl-2 Family;CDK;Influenza Virus;Orthopoxvirus;SARS-CoV
Isoform
– Bax;Bcl-2;CDK2
Pathway
– Anti-infection;Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
