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Amantadine
$30
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Products Details
Product Description
– Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson’s disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[1][2][3][4][5][6].
Web ID
– HY-B0402
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C10H17N
References
– [1]Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52. |[2]Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 24;13(4):539. |[3]Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct;121(4):773-85.|[4]Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 2015;36(3):904-910.|[5]Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200.|[6]Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099.
CAS Number
– 768-94-5
Molecular Weight
– 151.25
Compound Purity
– 98.0
SMILES
– NC12C[C@H]3C[C@@H](C2)C[C@@H](C1)C3
Clinical Information
– Launched
Research Area
– Cancer; Infection; Neurological Disease
Solubility
– DMSO : 10 mg/mL (ultrasonic;adjust pH to 2 with 1M HCl)
Target
– Apoptosis;Bcl-2 Family;CDK;Influenza Virus;Orthopoxvirus;SARS-CoV
Isoform
– Bax;Bcl-2;CDK2
Pathway
– Anti-infection;Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
