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Products Details
Product Description
– AM-8735 is a potent and selective MDM2 inhibitor with an IC50 of 25 nM.
Web ID
– HY-12734
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C27H31Cl2NO6S
References
– [1]Gonzalez AZ, et al. Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction. J Med Chem. 2014 Mar 27;57(6):2472-88.
CAS Number
– 1429386-01-5
Molecular Weight
– 568.51
SMILES
– O=C(N1[C@H](CS(=O)(C(C)(C)C)=O)C2CC2)[C@@H](CC(O)=O)O[C@H](C3=CC=CC(Cl)=C3)[C@H]1C4=CC=C(Cl)C=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– E1/E2/E3 Enzyme;MDM-2/p53
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
