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Products Details
Product Description
– AM-7209 is a potent and selective MDM2-p53 interaction inhibitor with a Kd of 38 pM. AM-7209 inhibits the MDM2 amplified SJSA-1 osteosarcoma cell line with an IC50 of 1.6 nM. AM-7209 shows antitumor activities[1].
Web ID
– HY-12941
Shipping
– Room temperature
Molecular Formula
– C37H41Cl2FN2O7S
References
– [1]Yosup Rew, et al. Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction. J Med Chem. 2014 Dec 26;57(24):10499-511.
CAS Number
– 1623432-51-8
Molecular Weight
– 747.70
SMILES
– O=C(O)C1=CC=C(NC(C[C@]2(C)C(N([C@@H](C3CC3)CS(=O)(C(C)(C)C)=O)[C@H](C4=CC=C(Cl)C(F)=C4)[C@@H](C5=CC=CC(Cl)=C5)C2)=O)=O)C=C1OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MDM-2/p53
Pathway
– Apoptosis
Product type
– Reference compound
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