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ALV2
$450 – $3,900
Products Details
Product Description
– ALV2 is a potent and selective Helios degrader. ALV2 binds CRBN, with an IC50 of 0.57 μM. Helios is the zinc-finger transcription factor that can maintain a stable Treg cell phenotype in the inflammatory tumor microenvironment[1].
Web ID
– HY-137206
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C26H26ClN5O5
References
– [1]Wang ES, et, al. Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat Chem Biol. 2021 Jun;17(6):711-717.
CAS Number
– 2438124-95-7
Molecular Weight
– 523.97
Compound Purity
– 98.07
SMILES
– O=C(NC(C)(C1=CC=CC(NC2=CC(N(C(CC3)C(NC3=O)=O)C2=O)=O)=C1)C)NC4=CC=C(C)C(Cl)=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 160 mg/mL (ultrasonic)
Target
– Ligands for E3 Ligase;Molecular Glues
Pathway
– PROTAC
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
