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Products Details
Product Description
– ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes[1].
Web ID
– HY-155408
Shipping
– Room temperature
Molecular Formula
– C19H22O3
References
– [1]Cerchia C et al. Identification of selective 5-LOX and FLAP inhibitors as novel anti-inflammatory agents by ligand-based virtual screening. Eur J Med Chem. 2023 Nov 8;263:115932.
CAS Number
– 903639-13-4
Molecular Weight
– 298.38
SMILES
– OC1=CC=C(C=C1)CCC2CCC(CO2)C3=CC=C(C=C3)O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– FLAP
Pathway
– Immunology/Inflammation
Product type
– Reference compound
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