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Alprenolol
SKU
HY-B1517-100 mg
Category Reference compound
Tags 5-HT Receptor, Cancer, GPCR/G Protein;Neuronal Signaling
$61 – $99
Products Details
Product Description
– Alprenolol ((RS)-Alprenolol; dl-Alprenolol) is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent[1][2][3].
Web ID
– HY-B1517
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C15H23NO2
Citations
– bioRxiv. 2020 Jan.|J Chromatogr B. 2023 Jun 20, 123804.|J Pharmaceut Biomed. 2020, 113870.|Nat Commun. 2020 Sep 25;11(1):4857.|Nat Chem Biol. 2023 Aug 14.
References
– [1]Himori N, et al. Effects of beta-adrenoceptor blocking agents, pindolol, alprenolol and practolol on blood pressure and heart rate in conscious renal hypertensive dogs. Arch Int Pharmacodyn Ther. 1977 Jan;225(1):152-65.|[2]Fernández-Guasti A, et al. Evidence for the involvement of the 5-HT1A receptor in the anxiolytic action of indorenate and ipsapirone. Psychopharmacology (Berl). 1990;101(3):354-8.|[3]Parratt JR, et al. Myocardial and haemodynamic effects of the beta-adrenoceptor blocking drug alprenolol (H56/28) in anaesthetized cats. Br J Pharmacol. 1969 Oct;37(2):357-66.
CAS Number
– 13655-52-2
Molecular Weight
– 249.35
Compound Purity
– 99.87
SMILES
– OC(COC1=CC=CC=C1CC=C)CNC(C)C
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)|H2O : 0.67 mg/mL (ultrasonic)
Target
– 5-HT Receptor
Isoform
– 5-HT1 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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