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Products Details
Product Description
– ALPK1-IN-1 (Compound A001) is a potent inhibitor of alpha-kinase 1 (ALPK1). ALPK1 is an intracytoplasmic serine threonine protein kinase that plays an important role in activating the innate immune response to bacteria via TRAF-interacting protein with forkhead-associated domain (TIFA) dependent proinflammatory NF-κB signaling[1].
Web ID
– HY-147561
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C25H32N6O2S
References
– [1]Danyang Liu, et al. Alpha protein kinase 1 inhibitors and methods of use. WO2022063152A1.
CAS Number
– 2765457-72-3
Molecular Weight
– 480.63
SMILES
– COC1=CC=C(C=C1)C(C)(C2=CSC(NC(NC(C3=CN=C(C=C3)N4CCNCC4)C)=O)=N2)C
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Infection
Solubility
– 10 mM in DMSO
Target
– NF-κB
Pathway
– NF-κB
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
