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Alosetron (Hydrochloride)
$32 – $280
Products Details
Product Description
– Alosetron Hydrochloride (GR 68755C) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron Hydrochloride attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects[1][2].
Web ID
– HY-70050C
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C17H19ClN4O
References
– [1]Balfour JA, Goa KL, Perry CM. Alosetron. Drugs. 2000;59(3):511-520.|[2]Motavallian A, et al. Anti-inflammatory effects of alosetron mediated through 5-HT3 receptors on experimental colitis. Res Pharm Sci. 2019;14(3):228-236.|[3]Targeting the 5-HT3 receptor in the treatment of irritable bowel syndrome By Spiller, Robin C. From Current Opinion in Pharmacology (2011), 11(1), 68-74.|[4]Lucak SL.
Optimizing outcomes with alosetron hydrochloride in severe diarrhea-predominant irritable bowel syndrome.
Therap Adv Gastroenterol. 2010 May;3(3):165-72.|[5]Lewis JH.
Alosetron for severe diarrhea-predominant irritable bowel syndrome: safety and efficacy in perspective.
Expert Rev Gastroenterol Hepatol. 2010 Feb;4(1):13-29.|[6]Turgeon DK, Tayeh N, Fontana RJ.
Acute hepatitis associated with alosetron (Lotronex).
J Clin Gastroenterol. 2005 Aug;39(7):641-2.|[7]Miller DP, Alfredson T, Cook SF, Sands BE, Walker AM.
Incidence of colonic ischemia, hospitalized complications of constipation, and bowel surgery in relation to use of alosetron hydrochloride.
Am J Gastroenterol. 2003 May;98(5):1117-22.
CAS Number
– 122852-69-1
Molecular Weight
– 330.81
Compound Purity
– 99.76
SMILES
– O=C(C(C1=C2C=CC=C1)=C(N2C)CC3)N3CC4=C(NC=N4)C.[H]Cl
Clinical Information
– Launched
Research Area
– Neurological Disease
Solubility
– H2O : 33.33 mg/mL (ultrasonic)
Target
– 5-HT Receptor
Isoform
– 5-HT3 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
