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Alofanib
SKU
HY-17601-10 mg
Category Reference compound
Tags Apoptosis;FGFR, Apoptosis;Protein Tyrosine Kinase/RTK, Cancer; Cardiovascular Disease
$90 – $600
Products Details
Product Description
– Alofanib (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2). Anticancer and antiangiogenic activity[1][2].
Web ID
– HY-17601
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C19H15N3O6S
References
– [1]Tsimafeyeu I, et al. Targeting FGFR2 with alofanib (RPT835) shows potent activity in tumour models. Eur J Cancer. 2016 Jul;61:20-8.|[2]Khochenkov DA, et al. Antiangiogenic Activity of Alofanib, an Allosteric Inhibitor of Fibroblast Growth Factor Receptor 2. Bull Exp Biol Med. 2015 Nov;160(1):84-7.
CAS Number
– 1612888-66-0
Molecular Weight
– 413.40
Compound Purity
– 98.81
SMILES
– O=C(O)C1=CC=CC(S(=O)(NC2=CC(C3=CC=CN=C3)=C(C)C=C2[N+]([O-])=O)=O)=C1
Clinical Information
– Phase 1
Research Area
– Cancer; Cardiovascular Disease
Solubility
– DMSO : ≥ 30.1 mg/mL
Target
– Apoptosis;FGFR
Isoform
– FGFR2
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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