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Products Details
Product Description
– Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC50: 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα[1].
Web ID
– HY-N11996
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C13H12O5
References
– [1]Sun Y N. et al. Isolation and identification of chromone and pyrone constituents from Aloe and their anti-inflammatory activities[J]. Journal of Functional Foods, 2016, 21: 232-239.|[2]Sun Y N, et al. Isolation and identification of chromone and pyrone constituents from Aloe and their anti-inflammatory activities[J]. Journal of Functional Foods, 2016, 21: 232-239.
CAS Number
– 59163-53-0
Molecular Weight
– 248.23
SMILES
– O=C1OC(C2=C(C)C=C(O)C=C2O)=CC(OC)=C1
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– NF-κB;NO Synthase
Pathway
– Immunology/Inflammation;NF-κB
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
