Download Files:
ALK2-IN-2
$350 – $2,250
Products Details
Product Description
– ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) with an IC50 of 9 nM, and over 700-fold selectivity against ALK3[1].
Web ID
– HY-112815
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C28H27N5O2S
References
– [1]Jiang JK, et al. Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3356-3362.
CAS Number
– 2254409-25-9
Molecular Weight
– 497.61
Compound Purity
– 99.56
SMILES
– CC(N1CCCC1)C(C=C2)=CC=C2C(C=N3)=CN4C3=C(C5=CC=C(S(=O)(N)=O)C6=C5C=CC=C6)C=N4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– TGF-β Receptor
Isoform
– ALK2
Pathway
– TGF-beta/Smad
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
