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Products Details
Product Description
– ALK-IN-9 (compound 40) is a potent ALK inhibitor. ALK-IN-9 inhibits cell proliferation with IC50s of <0.2 nM, <0.2 nM, 0.2 nM for Ba/F3-EML4-ALK, KM 12 (TPM3-TRKA), KG-l cell (OP2-FGFR1), respectively[1].
Web ID
– HY-131244
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H21FN6O3
References
– [1]Evan W. ROGERS, et al. Inhibiteurs macrocycliques de kinase et leur utilisation. US20160159741A1.
CAS Number
– 2359662-39-6
Molecular Weight
– 412.42
SMILES
– O=C1NC(C)(COC2=C(CN3C4=NC5=C1C=NN5C=C4OC[C@H]3C)C=C(F)C=N2)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Anaplastic lymphoma kinase (ALK)
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
