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ALK/EGFR-IN-1
SKU
HY-155227-Get quote
Category Reference compound
Tags Anaplastic lymphoma kinase (ALK);Apoptosis;EGFR, Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK, Cancer
Products Details
Product Description
– ALK/EGFR-IN-1 (Compound 8l) is an ALK/EGFR dual inhibitor that blocks the phosphorylation of EGFR and ALK. ALK/EGFR-IN-1 inhibits ALK/EGFR mutants respectively, with IC50 of 4.3 nM for EGFR L858R T790M in H1975 cells and EML4-ALK in BaF3 cells, respectively. and 3.6 nM. ALK/EGFR-IN-1 may be used in NSCLC research[1].
Web ID
– HY-155227
Shipping
– Room temperature
Molecular Formula
– C27H34ClN7O3S
References
– [1]An B, et al. Discovery of potent and effective inhibitors containing sulfoxide structures targeting EML4-ALK rearrangement and EGFR mutant non-small cell lung cancer. Bioorg Chem. 2023 Sep;138:106653.
CAS Number
– 2730430-08-5
Molecular Weight
– 572.12
SMILES
– O=S(CC)C1=C(NC2=NC(NC3=C(OC)C=C(N(CCN(C)C)C)C(NC(C=C)=O)=C3)=NC=C2Cl)C=CC=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Anaplastic lymphoma kinase (ALK);Apoptosis;EGFR
Pathway
– Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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