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Products Details
Product Description
– Alicaforsen sodium is a 20-base antisense oligonucleotide inhibiting ICAM-1 production, which is an important adhesion molecule involved in leukocyte migration and trafficking to the site of inflammation.
Web ID
– HY-145728A
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C192H225N75Na19O98P19S19
References
– [1]Henry SP, et al. Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a four-week study in cynomolgus monkeys. Toxicology. 1997;120(2):145-155.|[2]Henry SP, et al. Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a 4-week study in CD-1 mice. Antisense Nucleic Acid Drug Dev. 1997;7(5):473-481.
CAS Number
– 331257-52-4
Molecular Weight
– 6781.27
SMILES
– [Alicaforsen (sodium)]
Clinical Information
– Phase 3
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Integrin
Pathway
– Cytoskeleton
Product type
– Oligonucleotides
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
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