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Alcaftadine
SKU
HY-17039-10 mg
Category Reference compound
Tags GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling, Histamine Receptor, Inflammation/Immunology; Endocrinology
$42 – $290
Products Details
Product Description
– Alcaftadine (R89674) is a histamine H1 receptor antagonist, which is used to prevent eye irritation brought on by allergic conjunctivitis. Alcaftadine is a broad-spectrum antihistamine displaying a high affinity for histamine H1 and H2 receptors and a lower affinity for H4 receptors. Alcaftadine also exhibits modulatory action on immune cell recruitment and mast cell stabilizing effects[1][2].
Web ID
– HY-17039
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H21N3O
References
– [1]Namdar, R. and C. Valdez, Alcaftadine: a topical antihistamine for use in allergic conjunctivitis. Drugs Today (Barc), 2011. 47(12): p. 883-90.|[2]Mahvan, T.D., W.A. Buckley, and J.R. Hornecker, Alcaftadine for the prevention of itching associated with allergic conjunctivitis. Ann Pharmacother, 2012. 46(7-8): p. 1025-32.
CAS Number
– 147084-10-4
Molecular Weight
– 307.39
Compound Purity
– 99.43
SMILES
– O=CC1=CN=C2N1CCC3=CC=CC=C3/C2=C4CCN(C)CC4
Clinical Information
– Launched
Research Area
– Inflammation/Immunology; Endocrinology
Solubility
– DMSO : ≥ 40 mg/mL
Target
– Histamine Receptor
Isoform
– H1 Receptor;H2 Receptor
Pathway
– GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
Product type
– Reference compound
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