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Products Details
Product Description
– Akt1/Akt2-IN-2 (compound 7) is an allosteric dual Akt1 and Akt2 inhibitor (IC50=138 nM and 212 nM, respectively). Akt1/Akt2-IN-2 increases activity of caspase-3, and inhibits viability of a number of tumor cells[1].
Web ID
– HY-129119
Shipping
– Room temperature
Molecular Formula
– C40H43N7O2
References
– [1]Zhao Z, et al. Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity. Bioorg Med Chem Lett. 2008 Jan 1;18(1):49-53.
CAS Number
– 612847-42-4
Molecular Weight
– 653.82
SMILES
– O=C(C1=CC=C2N=C(C3=CC=CC=C3)C(C4=CC=C(CN5CCC(N6C7=CC=CC=C7NC6=O)CC5)C=C4)=NC2=C1)NCCN(CC)CC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Akt;Caspase
Isoform
– Akt1;Akt2;Akt3;Caspase 3
Pathway
– Apoptosis;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
