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Products Details
Product Description
– Akt/ROCK-IN-1 (B12) is a dual inhibitor for Akt and ROCK, with the IC50s of 0.023 nM and 1.47 nM, respectively. Akt/ROCK-IN-1 has antitumor activity for neuroblastoma[1].
Web ID
– HY-156796
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C21H19BrF2N4O2S
References
– [1]Jinxin Che, et al. Discovery of Novel Oxazepine Derivatives as Akt/ROCK Inhibitors for Growth Arrest and Differentiation Induction in Neuroblastoma Treatment. J Med Chem. 2023 Oct 12;66(19):13530-13555.
Molecular Weight
– 509.37
SMILES
– O=C(C(S1)=CC2=C1OCCN3C2=C(Br)C=N3)N[C@@H]4CNCC[C@H]4C5=CC=C(F)C(F)=C5
Clinical Information
– No Development Reported
Research Area
– Cancer; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Akt;ROCK
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton;PI3K/Akt/mTOR;Stem Cell/Wnt;TGF-beta/Smad
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
