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Products Details
Product Description
– AKT-IN-2 is a potent, selective and orally bioavailable AKT inhibitor with an IC50 of 5 nM for AKT1[1].
Web ID
– HY-112148
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C25H34F3N7O
References
– [1]Parthasarathy S, et al. Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1887-1891.
CAS Number
– 1295514-91-8
Molecular Weight
– 505.58
SMILES
– O=C1C[C@@H](C)C2=C(N3CCC(C4=NC(CCC(F)(F)F)=CN4CCN5CCCC5)CC3)N=CN=C2N1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Akt
Isoform
– Akt1
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
