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Products Details
Product Description
– AKR1C3-IN-10 (compound 5r) is a selective AKR1C3 inhibitor (IC50=51 nM). AKR1C3-IN-10 shows good activity in a prostate cancer xenograft model[1].
Web ID
– HY-155502
Shipping
– Room temperature
Molecular Formula
– C24H20N4O3
References
– [1]Maddeboina K, et al. Aldo-Keto Reductase 1C3 Inhibitor Prodrug Improves Pharmacokinetic Profile and Demonstrates In Vivo Efficacy in a Prostate Cancer Xenograft Model. J Med Chem. 2023 Jul 27;66(14):9894-9915.
Molecular Weight
– 412.44
SMILES
– O=C(C1=CC(C(C=C2)=CN3C2=NC=N3)=CC(/C=C/C(O)=O)=C1)NCC4=CC=C(C=C4)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Aldose Reductase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
