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Products Details
Product Description
– AhR modulator-1 (compound 6-MCDF) is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. AhR modulator-1 inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. AhR modulator-1 also possess anti-estrogenic properties in rat uterus[1].
Web ID
– HY-135671
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C13H7Cl3O
References
– [1]Fritz WA, et al. The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice. Biochem Pharmacol. 2009 Apr 1;77(7):1151-60.|[2]Koliopanos A, et al. Increased arylhydrocarbon receptor expression offers a potential therapeutic target for pancreatic cancer. Oncogene. 2002 Sep 5;21(39):6059-70.
CAS Number
– 118174-38-2
Molecular Weight
– 285.55
SMILES
– CC1=C(OC2=CC(Cl)=CC(Cl)=C23)C3=CC(Cl)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer; Endocrinology
Solubility
– 10 mM in DMSO
Target
– Aryl Hydrocarbon Receptor;Estrogen Receptor/ERR;VEGFR
Pathway
– Immunology/Inflammation;Protein Tyrosine Kinase/RTK;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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