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Agrimol B
$191 – $686
Products Details
Product Description
– Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27[1][2][3].
Web ID
– HY-N0704
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C37H46O12
References
– [1]Agrimol B, et al. Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway. Biochem Biophys Res Commun. 2016 Aug 26;477(3):454-60.|[2]Hnit SST, et al. Agrimol B present in Agrimonia pilosa Ledeb impedes cell cycle progression of cancer cells through G0 state arrest. Biomed Pharmacother. 2021 Sep;141:111795. |[3]Chun S B, et al. Antibacterial Activities against Plant Pathogens and Identification of Agrimol B from Agrimonia pilosa LEDEB[J]. 농약과학회지 제10권 3호, 2006, 10(3):230-236.
CAS Number
– 55576-66-4
Molecular Weight
– 682.75
Compound Purity
– 99.75
SMILES
– CC[C@H](C)C(C1=C(O)C(CC2=C(O)C(C(CCC)=O)=C(OC)C(C)=C2O)=C(O)C(CC3=C(O)C(C(CCC)=O)=C(OC)C(C)=C3O)=C1O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection; Metabolic Disease
Solubility
– DMSO : 5.56 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Bacterial;c-Myc;Fatty Acid Synthase (FASN);PPAR;Sirtuin
Isoform
– PPARγ;SIRT1
Pathway
– Anti-infection;Apoptosis;Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
