Download Files:
Products Details
Product Description
– AFM32a (PAD2-IN-1), a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. AFM32a shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold)[1].
Web ID
– HY-136557
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C25H29FN6O3
References
– [1]Aaron Muth, et al. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017 Apr 13;60(7):3198-3211.
CAS Number
– 2095109-82-1
Molecular Weight
– 480.53
SMILES
– O=C(C1=CC=CC(CN2)=C1C2=O)N[C@H](C3=NC4=C(OCC)C=CC=C4N3C)CCCNC(CF)=N
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Protein Arginine Deiminase
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
