AFM32a

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Products Details

Product Description

– AFM32a (PAD2-IN-1), a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. AFM32a shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold)[1].

Web ID

– HY-136557

Shipping

– Room temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C25H29FN6O3

References

– [1]Aaron Muth, et al. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017 Apr 13;60(7):3198-3211.

CAS Number

– 2095109-82-1

Molecular Weight

– 480.53

SMILES

– O=C(C1=CC=CC(CN2)=C1C2=O)N[C@H](C3=NC4=C(OCC)C=CC=C4N3C)CCCNC(CF)=N

Clinical Information

– No Development Reported

Research Area

– Cancer; Inflammation/Immunology

Solubility

– 10 mM in DMSO

Target

– Protein Arginine Deiminase

Pathway

– Epigenetics

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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