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Products Details
Product Description
– Afegostat is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1].
Web ID
– HY-14829
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C6H13NO3
References
– [1]Richter F, et al. A GCase chaperone improves motor function in a mouse model of synucleinopathy. Neurotherapeutics. 2014 Oct;11(4):840-56.
CAS Number
– 169105-89-9
Molecular Weight
– 147.17
SMILES
– O[C@@H]1CNC[C@H](CO)[C@H]1O
Clinical Information
– Phase 2
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Glucosidase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
