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Products Details
Product Description
– Afacifenacin (SMP-986) is a potent and orally active muscarinic receptor antagonist. Afacifenacin inhibits the bladder afferent pathway through the sodium-channel blockade, increasing volume, and reducing the frequency of urination and incontinence. Afacifenacin has the potential for the research of overactive bladder (OAB)[1][2].
Web ID
– HY-14828
Shipping
– Room temperature
Molecular Formula
– C27H26F3N3O2
References
– [1]Yeo EK, et al. New therapies in the treatment of overactive bladder. Expert Opin Emerg Drugs. 2013 Sep;18(3):319-37. |[2]Natsuko Goto, et al. Dual inhibition of Na+-channel and muscarinic receptor by SMP-986 efficiently improved voiding function compared to anti-muscarinic agents in two conscious rat models of detrusor overactivity. The Journal of Urology. 2008, 179, 129.
CAS Number
– 877606-63-8
Molecular Weight
– 481.51
SMILES
– O=C1NC2=C(C=CC=C2)[C@H](C3=CC=CC=C3)N1C4CCN(CC5=CC=CC(OC(F)(F)F)=C5)CC4
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– mAChR
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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