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Products Details
Product Description
– ACT-777991 is an orally active and selective CXCR3 antagonist. ACT-777991 has microsomes and hepatocytes stability across animal models. ACT-777991 inhibits the migration of activated T cells toward CXCL11[1].
Web ID
– HY-149055
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H20F6N8O2S
References
– [1]Meyer EA, et al. Discovery of Clinical Candidate ACT-777991, a Potent CXCR3 Antagonist for Antigen-Driven and Inflammatory Pathologies. J Med Chem. 2023 Mar 23;66(6):4179-4196.
CAS Number
– 1967811-46-6
Molecular Weight
– 550.48
SMILES
– OCC[C@@H](N(C(CN1C=NC(C)=N1)=O)CC2)CN2C(SC(C(F)(F)F)=N3)=C3C4=CN=C(C(F)(F)F)N=C4
Clinical Information
– Phase 1
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– CXCR
Isoform
– CXCR3
Pathway
– GPCR/G Protein;Immunology/Inflammation
Product type
– Reference compound
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