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Products Details
Product Description
– ACT-373898 is an inactive carboxylic acid metabolite of Macitentan. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist[1].
Web ID
– HY-135500
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C15H17BrN4O5S
References
– [1]Shirin Bruderer, et al. Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist. AAPS J. 2012 Mar;14(1):68-78.
CAS Number
– 1433875-14-9
Molecular Weight
– 445.29
SMILES
– O=C(O)COC1=NC=NC(NS(=O)(NCCC)=O)=C1C2=CC=C(Br)C=C2
Clinical Information
– No Development Reported
Research Area
– Endocrinology
Solubility
– 10 mM in DMSO
Target
– Endothelin Receptor
Isoform
– ETA;ETB
Pathway
– GPCR/G Protein
Product type
– Reference compound
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