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Products Details
Product Description
– AChE/PDE4-IN-1 (compound 12c) is a potent and selective dual PDE4/AChE inhibitor, with IC50s of 0.28 μM and 1.88 μM for AChE and PDE4D, respectively. AChE/PDE4-IN-1 exhibits anti-neuroinflammatory effect for the research of Alzheimer’s disease[1].
Web ID
– HY-147846
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C23H28N2O3
References
– [1]Liu J, et, al. Discovery of novel 2,3-dihydro-1H-inden-1-ones as dual PDE4/AChE inhibitors with more potency against neuroinflammation for the treatment of Alzheimer’s disease. Eur J Med Chem. 2022 Aug 5;238:114503.
Molecular Weight
– 380.48
SMILES
– COC1=C(C=C2C(C(CC2=C1)CC3=CC=CN=C3)=O)OCCN4CCCCC4
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Cholinesterase (ChE);Phosphodiesterase (PDE)
Isoform
– AChE;PDE4
Pathway
– Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
