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Products Details
Product Description
– AChE-IN-14 (compound 5) is a potent cholinesterase inhibitor with IC50s of 0.46 , 0.48, and 0.44 μM for electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hAChE), and equine serum butyrylcholinesterase (eqBuChE), respectively. AChE-IN-14 exhibits high affinity toward human H3 receptor (H3R; Ki= 159.8 nM). AChE-IN-14 can be used for the research of Alzheimer’s disease[1].
Web ID
– HY-146035
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C28H35NO3
References
– [1]Marek Bajda, et al. Search for new multi-target compounds against Alzheimer’s disease among histamine H<sub>3</sub> receptor ligands. Eur J Med Chem. 2020 Jan 1;185:111785.
CAS Number
– 2390042-05-2
Molecular Weight
– 433.58
SMILES
– O=C1C=C(C2=CC=C(OCCCCCCN3CCCCCC3)C=C2)OC4=CC=C(C)C=C14
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Cholinesterase (ChE);Histamine Receptor
Isoform
– AChE
Pathway
– GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
