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Product Description
– AChE-IN-12 is a potent and blood-brain barrier (BBB) penetrant acetylcholinesterase (AChE) with IC50s of 0.41 μM and 1.88 μM for rat AChE and electric eel AChE. AChE-IN-12 is also a good antioxidant (ORAC = 3.3 eq), selective metal chelator and huMAO-B inhibitor (IC50 = 8.8 µM). AChE-IN-12 has remarkable inhibition of self- and Cu2+-induced Aβ1-42 aggregation, as well as exhibits a good neuroprotective effect. AChE-IN-12 can be used for researching Alzheimer’s disease[1].
Web ID
– HY-144790
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C33H41NO7
References
– [1]Sang Z, Song Q, Cao Z, Deng Y, Zhang L. Design, synthesis, and evaluation of chalcone-Vitamin E-donepezil hybrids as multi-target-directed ligands for the treatment of Alzheimer’s disease. J Enzyme Inhib Med Chem. 2022;37(1):69-85.
CAS Number
– 2764664-52-8
Molecular Weight
– 563.68
SMILES
– O=C(C1=C(O)C=C(OC)C(O)=C1OC)/C=C/C2=CC=C(OCCCCCCN(CC)CC3=CC=CC=C3OC)C=C2
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Amyloid-β;Cholinesterase (ChE);Monoamine Oxidase
Isoform
– AChE
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
