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Products Details
Product Description
– AChE/BChE-IN-12 (compound 10b), a 3,5-dimethoxy analogue, is a potent AChE, BChE, and β-secretase-1 (BACE-1) inhibitor, with IC50 values of 2.57, 3.26, and 10.65 μM, respectively. AChE/BChE-IN-12 crosses the blood-brain barrier via passive diffusion and inhibits the self-aggregation of amyloid-β monomers. AChE/BChE-IN-12 can be used for Alzheimer’s disease (AD) research[1].
Web ID
– HY-149211
Shipping
– Room temperature
Molecular Formula
– C23H21N3O6
References
– [1]Sharma A, et al. Synthesis and Biological Evaluation of Coumarin Triazoles as Dual Inhibitors of Cholinesterases and β-Secretase. ACS Omega. 2023 Mar 16;8(12):11161-11176.
Molecular Weight
– 435.43
SMILES
– COC1=CC(CN2C=C(N=N2)COC3=C(C4=C(C=C3)C=CC(O4)=O)C(C)=O)=CC(OC)=C1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Amyloid-β;Beta-secretase;Cholinesterase (ChE)
Isoform
– AChE;BACE1;BChE
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
