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AChE/BChE-IN-10
$85 – $450
Products Details
Product Description
– AChE/BChE-IN-10 (Compound 7b) is a potent dual AChE and BChE inhibitor with IC50 values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 shows good blood brain barrier permeability. AChE/BChE-IN-10 can inhibit Aβ-aggregation and be used in Alzheimer’s disease (AD) research[1].
Web ID
– HY-151368
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C26H30N2O2
References
– [1]Mohd Abdullaha, et al. Discovery of methoxy-naphthyl linked N-(1-benzylpiperidine) benzamide as a blood-brain permeable dual inhibitor of acetylcholinesterase and butyrylcholinesterase. Eur J Med Chem. 2020 Dec 1;207:112761.
CAS Number
– 2924824-48-4
Molecular Weight
– 402.53
Compound Purity
– 99.67
SMILES
– O=C(NCCC1CCN(CC2=CC=CC=C2)CC1)C3=CC=C4C=C(OC)C=CC4=C3
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Cholinesterase (ChE)
Isoform
– AChE;BChE
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
