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Products Details
Product Description
– AChE/BChE/BACE-1-IN-2 (Compound 4o) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.069, 0.127 and 0.097 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-2 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-2 has remarkable antioxidant potential[1].
Web ID
– HY-147659
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C18H20F2N2
References
– [1]Choubey PK, et al. Design, synthesis, and multitargeted profiling of N-benzylpyrrolidine derivatives for the treatment of Alzheimer’s disease. Bioorg Med Chem. 2020 Nov 15;28(22):115721.
CAS Number
– 1877000-20-8
Molecular Weight
– 302.36
SMILES
– FC1=CC(F)=C(C=C1)CNC2CCN(C2)CC3=CC=CC=C3
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Beta-secretase;Cholinesterase (ChE);ROS Kinase
Isoform
– AChE;BChE
Pathway
– Neuronal Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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