Download Files:
Products Details
Product Description
– AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential[1].
Web ID
– HY-147658
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C19H21F3N2O
References
– [1]Choubey PK, et al. Design, synthesis, and multitargeted profiling of N-benzylpyrrolidine derivatives for the treatment of Alzheimer’s disease. Bioorg Med Chem. 2020 Nov 15;28(22):115721.
CAS Number
– 1321361-13-0
Molecular Weight
– 350.38
SMILES
– FC(F)(OC1=CC=C(C=C1)CNC2CCN(C2)CC3=CC=CC=C3)F
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Beta-secretase;Cholinesterase (ChE);ROS Kinase
Isoform
– AChE;BChE
Pathway
– Neuronal Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
