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Products Details
Product Description
– AChE/BACE1/GSK3β-IN-1 is an orally active triple inhibitor of AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1 has effective inhibitory activity against AChE, BACE1 and GSK3β with IC50 values of 1.0 μM, 20 μM and 15 μM, respectively. AChE/BACE1/GSK3β-IN-1 has good blood-brain barrier penetrability, suitable bioavailability. AChE/BACE1/GSK3β-IN-1 can be used for the research of Alzheimer’s disease (AD)[1].
Web ID
– HY-151260
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C26H27FN2O4
References
– [1]Nan Wang, et al. Design, Synthesis, and Biological Evaluation of Notopterol Derivatives as Triple Inhibitors of AChE/BACE1/GSK3β for the Treatment of Alzheimer’s Disease. ACS Omega 2022, 7, 36, 32131–32152. Publication Date:August 30, 2022.
CAS Number
– 2866066-81-9
Molecular Weight
– 450.50
SMILES
– O=C1C=CC2=C(OCCCN3CCC(NCC4=CC(F)=CC=C4)CC3)C5=C(OC=C5)C=C2O1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Beta-secretase;Cholinesterase (ChE);GSK-3
Isoform
– AChE;BACE1;GSK-3β
Pathway
– Neuronal Signaling;PI3K/Akt/mTOR;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
