Acetylaszonalenin

$358

Only 1000 item(s) left in stock.

Products Details

Product Description

– Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [3H]-SP binding to human astrocytoma cells with a Ki of 170 μM[1][2].

Web ID

– HY-119552

Shipping

– Room temperature

Applications

– Neuroscience-Neuromodulation

Molecular Formula

– C25H25N3O3

References

– [1]Wen-Bing Yin, et al. Acetylaszonalenin biosynthesis in Neosartorya fischeri. Identification of the biosynthetic gene cluster by genomic mining and functional proof of the genes by biochemical investigation. J Biol Chem. 2009 Jan 2;284(1):100-109.|[2]C J Barrow, et al. Spiroquinazoline, a novel substance P inhibitor with a new carbon skeleton, isolated from Aspergillus flavipes. J Nat Prod. 1994 Apr;57(4):471-6.

CAS Number

– 42230-55-7

Molecular Weight

– 415.48

SMILES

– O=C1N2[C@@]([H])(C(NC3=CC=CC=C13)=O)C[C@]4([C@@]2(N(C5=C4C=CC=C5)C(C)=O)[H])C(C)(C=C)C

Clinical Information

– No Development Reported

Research Area

– Neurological Disease

Solubility

– 10 mM in DMSO

Target

– Endogenous Metabolite;Neurokinin Receptor

Isoform

– Microbial Metabolite;NK1

Pathway

– GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling

Product type

– Natural Products

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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